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SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 21 Reviews
8.8
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
Vitamin B12 reduces cardiovascular risks
Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.
Moderate relevance to findings
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
Vitamin deficiencies affect blood pressure
The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
Significant findings on hypertension
We set out to understand how serum folic acid (FA) and vitamin B12 (VB12) levels relate to elevated blood pressure in children and adolescents. Our research included both a nested case-control and a cohort study, focusing on participants from primary schools. We observed that participants with elevated blood pressure had notably lower levels of folic acid and vitamin B12 compared to those with normal blood pressure.
Moreover, these children also had higher levels of homocysteine, a substance that can be harmful in excessive amounts. Among those who were overweight and obese, we found that those with high blood pressure had even lower levels of folic acid. The data suggested a significant connection: higher levels of folic acid were associated with better blood pressure outcomes, and this relationship remained even after accounting for vitamin B12 and homocysteine levels.
Additionally, our cohort study highlighted that both systolic and diastolic blood pressure measurements were lower in children with high folic acid exposure compared to those with low exposure. Overall, our findings indicated that deficiencies in folic acid and vitamin B12 during childhood can contribute to elevated blood pressure, potentially influencing cardiovascular health. Therefore, it's important to ensure adequate intake of these vitamins, either through diet or supplementation.
Moreover, these children also had higher levels of homocysteine, a substance that can be harmful in excessive amounts. Among those who were overweight and obese, we found that those with high blood pressure had even lower levels of folic acid. The data suggested a significant connection: higher levels of folic acid were associated with better blood pressure outcomes, and this relationship remained even after accounting for vitamin B12 and homocysteine levels.
Additionally, our cohort study highlighted that both systolic and diastolic blood pressure measurements were lower in children with high folic acid exposure compared to those with low exposure. Overall, our findings indicated that deficiencies in folic acid and vitamin B12 during childhood can contribute to elevated blood pressure, potentially influencing cardiovascular health. Therefore, it's important to ensure adequate intake of these vitamins, either through diet or supplementation.
Read More
Most Useful Reviews
9.5
Enhances cardiovascular health
I trust the Now brand. I began supplementing my 83-year-old mother with methylcobalamin after consulting several doctors. It’s recommended for better absorption and aims to support her cardiovascular health, given her limited meat consumption.
Read More
9.5
Promotes health
I chose products from Now Foods for my 83-year-old mother based on their quality. I started her on methylcobalamin to improve cardiovascular and neurological health, especially since she consumes little meat.
Read More
9.5
Alleviates numbness
Excellent product! Although I didn't have a severe B12 deficiency, my symptoms like numbness have improved significantly, and I can now manage dental work without anaesthesia.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
8
Vitamin B12 reduces cardiovascular risks
Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.
Moderate relevance to findings
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
Vitamin deficiencies affect blood pressure
The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
Significant findings on hypertension
We set out to understand how serum folic acid (FA) and vitamin B12 (VB12) levels relate to elevated blood pressure in children and adolescents. Our research included both a nested case-control and a cohort study, focusing on participants from primary schools. We observed that participants with elevated blood pressure had notably lower levels of folic acid and vitamin B12 compared to those with normal blood pressure.
Moreover, these children also had higher levels of homocysteine, a substance that can be harmful in excessive amounts. Among those who were overweight and obese, we found that those with high blood pressure had even lower levels of folic acid. The data suggested a significant connection: higher levels of folic acid were associated with better blood pressure outcomes, and this relationship remained even after accounting for vitamin B12 and homocysteine levels.
Additionally, our cohort study highlighted that both systolic and diastolic blood pressure measurements were lower in children with high folic acid exposure compared to those with low exposure. Overall, our findings indicated that deficiencies in folic acid and vitamin B12 during childhood can contribute to elevated blood pressure, potentially influencing cardiovascular health. Therefore, it's important to ensure adequate intake of these vitamins, either through diet or supplementation.
Moreover, these children also had higher levels of homocysteine, a substance that can be harmful in excessive amounts. Among those who were overweight and obese, we found that those with high blood pressure had even lower levels of folic acid. The data suggested a significant connection: higher levels of folic acid were associated with better blood pressure outcomes, and this relationship remained even after accounting for vitamin B12 and homocysteine levels.
Additionally, our cohort study highlighted that both systolic and diastolic blood pressure measurements were lower in children with high folic acid exposure compared to those with low exposure. Overall, our findings indicated that deficiencies in folic acid and vitamin B12 during childhood can contribute to elevated blood pressure, potentially influencing cardiovascular health. Therefore, it's important to ensure adequate intake of these vitamins, either through diet or supplementation.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8.8
9.5
Improves brain health
B-12 is a vital part of my diet. I take it to boost my haemoglobin and relieve muscle pain from myositis. There’s evidence that sufficient B-12 can help prevent diseases like senile dementia and sclerosis in old age. I particularly recommend it for those over 50, dissolving one tablet daily under the tongue to avoid stomach upset.
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9.5
Lowers homocysteine
I trust Now Foods, so I chose their B-12. The pink cherry-flavoured tablets are delicious and help lower homocysteine, which reduces the risk of heart attacks and strokes. Additionally, B-12 is vital for producing choline, protecting against unbalanced diets and fatty liver disease.
9.5
Prevents cognitive decline
Vitamin B-12 is crucial for DNA and RNA creation, red blood cell development, and nerve cell health. Deficiency can lead to various health issues, including cognitive decline and depression. Hence, I recommend this product for its various health benefits.
9.5
Enhances cardiovascular health
I trust the Now brand. I began supplementing my 83-year-old mother with methylcobalamin after consulting several doctors. It’s recommended for better absorption and aims to support her cardiovascular health, given her limited meat consumption.
9.5
Promotes health
I chose products from Now Foods for my 83-year-old mother based on their quality. I started her on methylcobalamin to improve cardiovascular and neurological health, especially since she consumes little meat.
